Manganese peroxidase

Latest revision as of 17:45, 2 November 2012

Enzyme number :EC 1.11.1.13

▸Nomenclature Committee of the International Union of Biochemistry and Molecular Biology

▸Accepted name: manganese peroxidase (EC 1.11.1.13)

▸Reaction: 2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O

▸Other name(s): peroxidase-M2; Mn-dependent (NADH-oxidizing) peroxidase

▸Systematic name: Mn(II):hydrogen-peroxide oxidoreductase

▸Comments: A hemoprotein. Involved in the oxidative degradation of lignin in white rot basidiomycetes.

Fungal taxa : Basidiomycota
Localization : Extracellular

[edit] Catalytic cycle of manganese peroxidase

[edit] Reference

Detoxification and Metabolism of Chemicals by White-Rot Fungi | Steven D. Aust , Paul R. Swaner, and James D. Stah

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-Enzyme number :EC 1.11.1.13
+Enzyme number :EC 1.11.1.13 [[File:Enzyme manganase peroxidase.jpg | thumb | 200px]]
-H2O2 에 의존 하여 Mn2+ 를 Mn3+ 로 산화 시키고 , Mn3+ 가 유기 물질을 산화 시키게 된다 .
-iron protoporphyrin IX group 을 가지고 있는 glycoprotein 이다 .
-MnP는 다양한 phenol 과 dye 를 산화 시킬수 있다 .
+▸Nomenclature Committee of the International Union of Biochemistry and Molecular Biology
+▸Accepted name: manganese peroxidase (EC 1.11.1.13)
- As shown in Figure 4, the native enzyme reacts with H2O2 forming Compound I, which is then converted to Compound II by reacting with one equivalent of Mn(II) and forming Mn(III). A second Mn(II) is then used to reduce Compound II back to the native enzyme. Similarly, the MnP Compound I can be reduced by phenolic substrates, but at a slower rate. Phenolic compounds are, however, not able to reduce efficiently MnP Compound II back to the native enzyme. It may be that the FeIV=O center in MnP Compound II is partially buried and the site is not available to organic substrates. Thus, the enzyme is not able to complete its catalytic cycle without the presence of Mn(II) (Wariishi et al. 1988)
-*fungal taxa : Basidiomycota
+▸Reaction: 2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
-*Localization : Extracellular
+▸Other name(s): peroxidase-M2; Mn-dependent (NADH-oxidizing) peroxidase
-• H2O2-dependent one-electron oxidation of Mn2+ to Mn3+, which subsequently oxidizes organic compounds	• Redox potential of 1.0–1.2 V
-• Mn3+-mediated oxidation of various phenols and aromatic amines
+▸Systematic name: Mn(II):hydrogen-peroxide oxidoreductase
-• Extended substrate range in the presence of co-oxidants (organic SH-containing compounds, unsaturated fatty acids and their derivatives)
-• Activity in the acidic pH range	60,68,70
+▸Comments: A hemoprotein. Involved in the oxidative degradation of lignin in white rot basidiomycetes.
+*Fungal taxa : [[KUC Basidiomycota | Basidiomycota ]]
+*Localization : Extracellular
+==Catalytic cycle of manganese peroxidase ==
+[[File:Manganese peroxidase.GIF | 500 px ]]
+== Reference ==
+Detoxification and Metabolism of Chemicals by White-Rot Fungi | Steven D. Aust , Paul R. Swaner, and James D. Stah

From mycopedia

Latest revision as of 17:45, 2 November 2012

[edit] Catalytic cycle of manganese peroxidase

[edit] Reference