From CSBLwiki
In the current Metathesaurus, there are three sources of co-occurrence data:
MEDLINE, AI/RHEUM, and CCPSS. From MEDLINE, co-occurrence data was computed for concepts
that were designated as principal or main points in the same journal article i.e.,
the co-occurrence counts do not include articles in which either or both of the concepts
were present and indexed in MEDLINE but not designated as main points.
(A concept is considered to be a main point if the * is attached to the main heading
or any of its subheadings.)